Leone (Ambrogio) Novum opus quaestionum, collation: a⁴, A-P⁴, Roman type, title in red and within woodcut frame printed in blue, woodcut diagrams, woodcut printer's device to verso of penultimate f., final f. blank, marginal water-staining, fragments of medieval manuscripts used in binding, contemporary limp vellum, upper cover with ink title within 4 concentric circles, lacking ties, folio (315 x 217mm.), [Venice], [Bernardino & Matteo Vitali], 1523.

⁂ Scarce first edition of this miscellany by this Italian physician, mathematician, historian, and philosopher. 'The 'New Work of Questions' includes four hundred and four problems of very miscellaneous character. The majority deal with medicine and natural philosophy... Leone's longest discussion of any single question is that of the seventieth, which inquires why quicksilver, dissolved in oil or fat and used to anoint the heels or palms, within a week affects the gums and saliva. In this connection Leone gives a very good account of syphilis which deserves publication along with the other early tracts on that disease' (Thorndike).

Literature: Houzeau-Lancaster 2389; Riccardi I/2, 33; Sander 3915; Wellcome I, 3726; Thorndike V, 143; EDIT 16 CNCE 38060.